HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(methylsulfonyl)-3-(trifluoromethyl)benzylcarbamate | HCID 68071520 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride | HCID 66632607 | — |
Reaction Steps
tert-Butyl 4-(methylsulfonyl)-3-(trifluoromethyl)benzylcarbamate (420 mg, 1.18 mmol) was dissolved in CH2Cl2 (12 ml) and HCl in Et2O (3 ml, 2M) were added. Resulting mixture was stirred at room temperature overnight followed by evaporation to give 4-(methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride as white solids. This material was used in subsequent reactions without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-782fcc3b679d47b39dc9576ac79d3b39 |
| Source note | uspto-grants-2013_04 |