Hydrochloric Acid → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride

HRID 1961433Notes

Reaction equation

HRID 1961433 reaction equation
[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([CH2:9][NH:10]C(=O)OC(C)(C)C)=[CH:7][C:6]=1[C:20]([F:23])([F:22])[F:21])(=[O:4])=[O:3].[ClH:24]>C(Cl)Cl.CCOCC>[ClH:24].[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([CH2:9][NH2:10])=[CH:7][C:6]=1[C:20]([F:21])([F:22])[F:23])(=[O:4])=[O:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68071520tert-Butyl 4-(methylsulfonyl)-3-(trifluoromethyl)benzylcarbamate

Product 1

HCID 666326074-(Methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(methylsulfonyl)-3-(trifluoromethyl)benzylcarbamate (420 mg, 1.18 mmol) was dissolved in CH2Cl2 (12 ml) and HCl in Et2O (3 ml, 2M) were added. Resulting mixture was stirred at room temperature overnight followed by evaporation to give 4-(methylsulfonyl)-3-(trifluoromethyl)benzylamine hydrochloride as white solids. This material was used in subsequent reactions without further purification.

Workup

  1. customResulting mixture
  2. customfollowed by evaporation

Sources & evidence

ORD record
ord-782fcc3b679d47b39dc9576ac79d3b39
Source dataset
uspto-grants-2013_04
Patent number
US08415333B2

Reaction notes

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