反应详情

355 mg (3.16 mmol) KOtBu and 14 μl (0.79 mmol) H2O were added to a solution of 386 mg (0.79 mmol) tert-butyl 4-(1-hydroxycyclohexyl)benzylcarbamate in 3.9 ml THF. Refluxed for 2 h. Cooled to r.t. The reaction was quenched with NH4Cl (sat.) and the pH was adjusted to 10-11 with 2 M NaOH. The mixture was extracted 3 times with EtOAc. The organic phase was dried (MgSO4) and concentrated. Gave 164 mg (quant. yield). Used directly in the next step.

1. temperatureRefluxed for 2 h
2. customThe reaction was quenched with NH4Cl (sat.)
3. extractionThe mixture was extracted 3 times with EtOAc
4. dry with materialThe organic phase was dried (MgSO4)
5. concentrationconcentrated
6. customGave 164 mg (quant. yield)