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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961468Generated: October 31, 2026

HCID 66633913, compound → 4-Chloro-2-methyl-N-(3-(trifluoromethyl)benzyl)-1,8-naphthyridine-3-carboxamide

https://huagongshe.com/reaction/1961468

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 66633913HCID 66633913—
ReactantHCID 66745469HCID 66745469—
Product4-Chloro-2-methyl-N-(3-(trifluoromethyl)benzyl)-1,8-naphthyridine-3-carboxamideHCID 6674608959%

Reaction Steps

This substance was synthesized from 2-Methyl-4-oxo-N-(3-(trifluoromethyl)benzyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide (130.0 mg, 0.36 mmol) following the same procedure used for ethyl 4-chloro-2-methyl-1,8-naphthyridine-3-carboxylate. Purification was done by flash chromatography (EtOAc/MeOH 100:0→96:4) giving 80.0 mg (59%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415333B2
Source datasetuspto-grants-2013_04
ORD IDord-c37dfe6cb80444d79bef53037c2fcd46
Source noteuspto-grants-2013_04