HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → N-(4-tert-butylbenzyl)-2,7-dimethyl-1,8-naphthyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Amino-6-methylnicotinaldehyde | HCID 53401030 | — |
| Reactant | N-(4-tert-butylbenzyl)-3-oxobutanamide | HCID 86661979 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(4-tert-butylbenzyl)-2,7-dimethyl-1,8-naphthyridine-3-carboxamide | HCID 66633995 | 51% |
Reaction Steps
A solution of 200 mg (1.47 mmol) 2-amino-6-methylnicotinaldehyde, 400 mg (1.62 mmol) N-(4-tert-butylbenzyl)-3-oxobutanamide and 15 (0.15 mmol) piperidine in 3 ml EtOH was refluxed for 36 h. The reaction mixture was concentrated under reduced pressure. Flash chromatography (CH2Cl2/MeOH 20:1) afforded 258 mg (51%) of the title compound as a yellow-brown amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f90a1ccde2e940e5bd13b52d3332c612 |
| Source note | uspto-grants-2013_04 |