反应详情

A solution of 200 mg (1.47 mmol) 2-amino-6-methylnicotinaldehyde, 400 mg (1.62 mmol) N-(4-tert-butylbenzyl)-3-oxobutanamide and 15 (0.15 mmol) piperidine in 3 ml EtOH was refluxed for 36 h. The reaction mixture was concentrated under reduced pressure. Flash chromatography (CH2Cl2/MeOH 20:1) afforded 258 mg (51%) of the title compound as a yellow-brown amorphous solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure