3-Amino-1-phenyl-1H-pyrazole-4-carbonitrile → 3-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)-1-phenyl-1H-pyrazole-4-carbonitrile

HRID 1961511Notes

Reaction equation

HRID 1961511 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[CH:5][N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.Br[C:16]1[CH:30]=[CH:29][C:19]([C:20]([N:22]2[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]2)=[O:21])=[CH:18][CH:17]=1>>[CH3:28][N:25]1[CH2:26][CH2:27][N:22]([C:20]([C:19]2[CH:29]=[CH:30][C:16]([NH:1][C:2]3[C:6]([C:7]#[N:8])=[CH:5][N:4]([C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=4)[N:3]=3)=[CH:17][CH:18]=2)=[O:21])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 27742493-Amino-1-phenyl-1H-pyrazole-4-carbonitrileHCID 44643521-(4-Bromobenzoyl)-4-methylpiperazine

Product 1

HCID 672534503-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)-1-phenyl-1H-pyrazole-4-carbonitrile

Procedure

3-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)-1-phenyl-1H-pyrazole-4-carbonitrile was prepared according to the general procedure in Example 7 Step 2 using 3-amino-1-phenyl-1H-pyrazole-4-carbonitrile (50 mg, 0.271 mmol) and 1-(4-bromobenzoyl)-4-methylpiperazine (77 mg, 0.271 mmol) as the starting materials.

Sources & evidence

ORD record
ord-bbd16f8b5d0d4c4db9701dc7b097f693
Source dataset
uspto-grants-2013_04
Patent number
US08415346B2

Reaction notes

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