3-Amino-1-phenyl-1H-pyrazole-4-carbonitrile → 3-{[4-(1-hydroxy-1-methylethyl)phenyl]amino}-1-phenyl-1H-pyrazole-4-carbonitrile

HRID 1961515Notes

Reaction equation

HRID 1961515 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[CH:5][N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.I[C:16]1[CH:21]=[CH:20][C:19]([C:22]([OH:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=1>>[OH:25][C:22]([C:19]1[CH:20]=[CH:21][C:16]([NH:1][C:2]2[C:6]([C:7]#[N:8])=[CH:5][N:4]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:3]=2)=[CH:17][CH:18]=1)([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 27742493-Amino-1-phenyl-1H-pyrazole-4-carbonitrileHCID 539961442-(4-Iodophenyl)propan-2-ol

Product 1

HCID 672554983-{[4-(1-hydroxy-1-methylethyl)phenyl]amino}-1-phenyl-1H-pyrazole-4-carbonitrile

Procedure

3-{[4-(1-hydroxy-1-methylethyl)phenyl]amino}-1-phenyl-1H-pyrazole-4-carbonitrile was prepared according to the general procedure in Example 11 Step 1 using 3-amino-1-phenyl-1H-pyrazole-4-carbonitrile (70 mg, 0.380 mmol) and 2-(4-iodophenyl)propan-2-ol (100 mg, 0.380 mmol) as the starting materials.

Sources & evidence

ORD record
ord-c2b45f6173824979af7182163e367d77
Source dataset
uspto-grants-2013_04
Patent number
US08415346B2

Reaction notes

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