Hydrochloric Acid → HCID 66625750, compound

HRID 1961636Notes

Reaction equation

HRID 1961636 reaction equation
[CH2:1]([N:8]1[CH2:24][CH2:23][C:11]2([O:13][C:12]2([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[O:14]C)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.O>CCOCC>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([C:12]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[O:14])([OH:13])[CH2:23][CH2:24]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86614570HCID 86614570, compound

Product 1

HCID 66625750HCID 66625750, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

6-Benzyl-2-(4-fluoro-phenyl)-2-methoxy-1-oxa-6-aza-spiro[2.5]octane (0.600 g, 1.83 mmol) was solved in ether (6 mL), 0.6 mL of aqueous HCl was added (37%) and the reaction mixture was stirred at room temperature. After 0.5 h the reaction was finished and water was added and the product precipitate. The mixture was filtrated and the solid was recrystallized ethanol/ether to yield the title compound as a white solid (0.550 g, 1.76 mmol, 96%). MS (m/e): 314.0 (M+H+).

Workup

  1. filtrationThe mixture was filtrated
  2. customthe solid was recrystallized ethanol/ether

Sources & evidence

ORD record
ord-52c4cbbed6e9463ea1b1b23fdf7c91f7
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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