HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (4-Fluorophenyl)-(4-methylpiperidin-4-yl)methanone;2,2,2-trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone | HCID 20530715 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-Fluorophenyl)-(4-methylpiperidin-4-yl)methanone;2,2,2-trifluoroacetic acid | HCID 86614571 | — |
Reaction Steps
The title compound was synthesized from (4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone (0.215 g, 0.6 mmol) and trifluoroacetic acid (1.4 mL, 6 mmol) in 5 mL of dichloromethane to yield 0.328 g of a yellow solid that was used on the next step without purification. MS (m/e): 222.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415350B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e8e77651044741768189044ec7974278 |
| Source note | uspto-grants-2013_04 |