Trifluoroacetic acid → (4-Fluorophenyl)-(4-methylpiperidin-4-yl)methanone;2,2,2-trifluoroacetic acid

HRID 1961640Notes

Reaction equation

HRID 1961640 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2([CH3:16])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2([CH3:16])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20530715(4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone

Product 1

HCID 86614571(4-Fluorophenyl)-(4-methylpiperidin-4-yl)methanone;2,2,2-trifluoroacetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was synthesized from (4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone (0.215 g, 0.6 mmol) and trifluoroacetic acid (1.4 mL, 6 mmol) in 5 mL of dichloromethane to yield 0.328 g of a yellow solid that was used on the next step without purification. MS (m/e): 222.3 (M+H+).

Sources & evidence

ORD record
ord-e8e77651044741768189044ec7974278
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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