1,3-Benzodioxole-5-carboxylic acid → HCID 178523663, compound

HRID 1961666Notes

Reaction equation

HRID 1961666 reaction equation
Cl.Cl.[NH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]([C:20]3[S:21][C:22]([Cl:25])=[CH:23][CH:24]=3)=[O:19])[CH2:14][CH2:13]2)[CH2:6][CH2:5]1.[O:26]1[C:30]2[CH:31]=[CH:32][C:33]([C:35](O)=[O:36])=[CH:34][C:29]=2[O:28][CH2:27]1>>[Cl:25][C:22]1[S:21][C:20]([C:18]([CH:15]2[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C@H:7]3[CH2:8][CH2:9][C@H:4]([NH:3][C:35]([C:33]4[CH:32]=[CH:31][C:30]5[O:26][CH2:27][O:28][C:29]=5[CH:34]=4)=[O:36])[CH2:5][CH2:6]3)[CH2:13][CH2:14]2)=[O:19])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 71961,3-Benzodioxole-5-carboxylic acidHCID 178478716HCID 178478716, compound

Product 1

HCID 178523663HCID 178523663, compound

Procedure

From {1-[2-(trans-4-amino-cyclohexyl)-ethyl]-piperidin-4-yl}-(5-chloro-thiophen-2-yl)-methanone dihydrochloride (100 mg) and benzo[1,3]dioxole-5-carboxylic acid (45 mg) by procedure C. Yield: 62 mg (52%). Off-white solid. MS (m/z): 503.2 ([M+H]+).

Sources & evidence

ORD record
ord-be551c9504f94002b617036f392ff4c6
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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