3-Fluorobenzenesulfonyl Chloride → HCID 57989836, compound

HRID 1961978Notes

Reaction equation

HRID 1961978 reaction equation
[CH3:1][C:2]([C:5]1[S:6][C:7]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][N:19]=2)=[C:8]([C:10]2[C:11]([F:17])=[C:12]([CH:14]=[CH:15][CH:16]=2)[NH2:13])[N:9]=1)([CH3:4])[CH3:3].[F:24][C:25]1[CH:26]=[C:27]([S:31](Cl)(=[O:33])=[O:32])[CH:28]=[CH:29][CH:30]=1>>[CH3:4][C:2]([C:5]1[S:6][C:7]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][N:19]=2)=[C:8]([C:10]2[C:11]([F:17])=[C:12]([NH:13][S:31]([C:27]3[CH:28]=[CH:29][CH:30]=[C:25]([F:24])[CH:26]=3)(=[O:33])=[O:32])[CH:14]=[CH:15][CH:16]=2)[N:9]=1)([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 57989889HCID 57989889, compound

Product 1

HCID 57989836HCID 57989836, compound

Procedure

Following a procedure analogous to the procedure described in Intermediate 14 using 3-[2-(1,1-dimethylethyl)-5-(4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluoroaniline (70 mg, 0.213 mmol) and 3-fluorobenzenesulfonyl chloride (124 mg, 0.639 mmol), the title compound was obtained as a solid (76 mg, 73% yield). MS (ESI): 488 [M+H]+.

Sources & evidence

ORD record
ord-fd3b4f5b376040ffabbd5e7c5c97e5e2
Source dataset
uspto-grants-2013_04
Patent number
US08415345B2

Reaction notes

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