Ammonium formate → HCID 57989774, compound

HRID 1962007Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])=[N:10][C:9]=2[C:17]2[C:18]([F:32])=[C:19]([NH:23][S:24]([C:27]3[CH:31]=[CH:30][O:29][CH:28]=3)(=[O:26])=[O:25])[CH:20]=[CH:21][CH:22]=2)[CH:5]=[CH:4][N:3]=1.C([O-])=O.[NH4+]>>[CH3:16][C:13]([C:11]1[S:12][C:8]([C:6]2[CH:5]=[CH:4][N:3]=[CH:2][N:7]=2)=[C:9]([C:17]2[C:18]([F:32])=[C:19]([NH:23][S:24]([C:27]3[CH:31]=[CH:30][O:29][CH:28]=3)(=[O:25])=[O:26])[CH:20]=[CH:21][CH:22]=2)[N:10]=1)([CH3:14])[CH3:15]

Participants

Reactant 2

HCID 2723923Ammonium formate

HCID 86636589HCID 86636589, compound

Product 1

HCID 57989774HCID 57989774, compound

Procedure

Following a procedure analogous to the procedure described in Example 26 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-furansulfonamide (77 mg, 0.156 mmol) and ammonium formate (98 mg, 1.562 mmol), the title compound was obtained as a yellow solid (23 mg, 30% yield). MS (ESI): 459 [M+H]+.

Sources & evidence

ORD record: ord-0ebd943e654f420c91489803b1260463
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415345B2

Reaction notes

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