Ammonium Hydroxide → HCID 57990039, compound

HRID 1962008Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][CH3:14])=[N:10][C:9]=2[C:15]2[C:16]([F:33])=[C:17]([NH:21][S:22]([C:25]3[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=3[F:32])(=[O:24])=[O:23])[CH:18]=[CH:19][CH:20]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[NH4+:35]>>[NH2:35][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][CH3:14])=[N:10][C:9]=2[C:15]2[C:16]([F:33])=[C:17]([NH:21][S:22]([C:25]3[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=3[F:32])(=[O:24])=[O:23])[CH:18]=[CH:19][CH:20]=2)[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 86636590HCID 86636590, compound

Product 1

HCID 57990039HCID 57990039, compound

Procedure

Following a procedure analogous to the procedure described in Example 52, Step B using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide (100 mg, 0.196 mmol) and ammonium hydroxide (3 mL, 77 mmol), the title compound was obtained as an off-white solid (52 mg, 51% yield). MS (ESI): 492 [M+H]+.

Sources & evidence

ORD record: ord-8ac138f0f0de4e018ded2e7efd407ca1
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415345B2

Reaction notes

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