Hydrochloric Acid → 2-Methyl-2-(4-nitrophenoxy)propanoic acid

HRID 1962256Notes

Reaction equation

HRID 1962256 reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][C:9]([CH3:15])([CH3:14])[C:10]([O:12]C)=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].Cl>CO.O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:15])([CH3:14])[C:10]([OH:12])=[O:11])=[CH:16][CH:17]=1)([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57562956Methyl 2-methyl-2-(4-nitrophenoxy)propanoate

Product 1

HCID 1769302-Methyl-2-(4-nitrophenoxy)propanoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Methyl 2-(4-nitrophenoxy)isobutyrate was dissolved in methanol (50 mL) and water (50 mL). Sodium hydroxide (5 g) was added. The solution was stirred at rt for 30 min, then acidified with 1N HCl aq. to pH ˜3. The aq. Solution was extracted with ethyl acetate (2×100 mL). The organic layers were evaporated to give 2-(4-nitrophenoxy)isobutyric acid.

Workup

  1. extractionThe aq. Solution was extracted with ethyl acetate (2×100 mL)
  2. customThe organic layers were evaporated

Sources & evidence

ORD record
ord-745eeb56afad409d9b033330c30167ad
Source dataset
uspto-grants-2013_04
Patent number
US08415365B2

Reaction notes

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