反应详情

A mixture of 3-tert-butyl-5-(methoxycarbonyl)benzoic acid (9.18 g, 38.9 mmol, prepared by the method of Carter et. al., WO2005021500A1), thionyl chloride (75 mL) and 1 drop of DMF in toluene (200 mL) was heated at reflux for 2 h, cooled and concentrated. The residue was azeotroped with toluene (3×50 mL) and dried under high vacuum to give the title compound as an off-white waxy solid (9.9 g, quantitative yield).

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. temperaturecooled
4. concentrationconcentrated
5. customThe residue was azeotroped with toluene (3×50 mL)
6. customdried under high vacuum