3-Aminopyridine → HCID 58286945, compound

HRID 1962402Notes

Reaction equation

HRID 1962402 reaction equation
[CH:1]1([C@H:5]([NH:13][C:14]([CH:16]([C:20]2[CH:28]=[C:27]([F:29])[CH:26]=[C:25]([F:30])[C:21]=2[C:22]([OH:24])=O)[C:17](=O)[CH3:18])=[O:15])[C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1>>[CH:1]1([C@H:5]([NH:13][C:14]([C:16]2[C:20]3[C:21](=[C:25]([F:30])[CH:26]=[C:27]([F:29])[CH:28]=3)[C:22](=[O:24])[N:31]([C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)[C:17]=2[CH3:18])=[O:15])[C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 58286949HCID 58286949, compound

Product 1

HCID 58286945HCID 58286945, compound

Procedure

The title compound was prepared analogously from 2-(1-{[(S)-Cyclobutyl-(3-fluoro-phenyl)-methyl]-carbamoyl}-2-oxo-propyl)-4,6-difluoro-benzoic acid and 3-aminopyridine (acetonitrile 90° C., 16 hours). LC-MS (m/z) 478.1 (MH+); tR=1.27.

Sources & evidence

ORD record
ord-8227eaf217654089be58e8721447ec85
Source dataset
uspto-grants-2013_04
Patent number
US08415356B2

Reaction notes

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