HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242852 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 16223985 | — |
Reaction Steps
Intermediate 1a (120 mg) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture was stirred at room temperature for 12 hours. The solvent was concentrated under reduced pressure, and the obtained solid was collected by filtration to obtain the title compound as hydrochloride (84 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-334c021098a8453baa66a3bfdf772bbb |
| Source note | uspto-grants-2013_04 |