Hydrochloride methanol → Hydrochloric Acid

HRID 1962422Notes

Reaction equation

HRID 1962422 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:28]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67242852(S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 16223985(S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Procedure

Intermediate 1a (120 mg) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture was stirred at room temperature for 12 hours. The solvent was concentrated under reduced pressure, and the obtained solid was collected by filtration to obtain the title compound as hydrochloride (84 mg).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationthe obtained solid was collected by filtration

Sources & evidence

ORD record
ord-334c021098a8453baa66a3bfdf772bbb
Source dataset
uspto-grants-2013_04
Patent number
US08415372B2

Reaction notes

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