Hydrochloride methanol → Hydrochloric Acid

HRID 1962446Notes

Reaction equation

C(O[C:6]([N:8]([C@H:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Br:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)C)=O)(C)(C)C.[ClH:29].CO>>[Br:28][C:20]1[C:19]2[C:18]([S:15]([N:12]3[CH2:13][CH2:14][C@H:10]([NH:8][CH3:6])[CH2:11]3)(=[O:16])=[O:17])=[CH:27][CH:26]=[CH:25][C:24]=2[CH:23]=[N:22][CH:21]=1.[ClH:29]

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 67245309HCID 67245309, compound

Product 2

HCID 313Hydrochloric Acid

HCID 67243898HCID 67243898, compound

Procedure

Intermediate 20a (0.157 g) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (125 mg).

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-daba36856a0141b1a2b829626728fc7a
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415372B2

Reaction notes

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