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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1962454Generated: November 3, 2026

3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid

https://huagongshe.com/reaction/1962454

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidineHCID 2761404—
Reactant(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl esterHCID 7171888—
Reactant3-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidineHCID 87322379—
ProductHydrochloric AcidHCID 313—
ProductHCID 178482263HCID 178482263—

Reaction Steps

3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 24) can be prepared by using 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, and then used in the method of Example 35-1, Step Bin a similar manner to obtain the title compound as hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415372B2
Source datasetuspto-grants-2013_04
ORD IDord-c7c57d589a5244fd9886b7d488f1af3d
Source noteuspto-grants-2013_04