Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 86627805 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178484867 | HCID 178484867 | — |
Reaction Steps
Intermediate 24a (168 mg) obtained in Step A mentioned above was added with 10% hydrogen chloride/methanol (4 ml), and the mixture was stirred at 60° C. for 30 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (123 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08415372B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-1fe18075f06543609f9ea5f8c0d8fab2 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
