Hydrochloride methanol → Hydrochloric Acid

HRID 1962455Notes

Reaction equation

HRID 1962455 reaction equation
C(OC([N:8]([C@H:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Br:29])=[CH:21][N:22]=[C:23]([Cl:28])[C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)[CH3:9])=O)(C)(C)C.Cl.C[OH:32]>>[OH:32][C:23]1[C:24]2[CH:25]=[CH:26][CH:27]=[C:18]([S:15]([N:12]3[CH2:13][CH2:14][C@H:10]([NH:8][CH3:9])[CH2:11]3)(=[O:17])=[O:16])[C:19]=2[C:20]([Br:29])=[CH:21][N:22]=1.[ClH:28]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86627805(S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 178484867HCID 178484867, compound

Conditions

Temperature
60 °C

Procedure

Intermediate 24a (168 mg) obtained in Step A mentioned above was added with 10% hydrogen chloride/methanol (4 ml), and the mixture was stirred at 60° C. for 30 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (123 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1fe18075f06543609f9ea5f8c0d8fab2
Source dataset
uspto-grants-2013_04
Patent number
US08415372B2

Reaction notes

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