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HRID1962459

反应详情

EQUATION

反应方程式

HRID 1962459 的结构方程式

REACTANTS

反应物

5
结构：CN(C(=O)OC(C)(C)C)C1CCNC1
HCID2761404

tert-Butyl methyl(pyrrolidin-3-yl)carbamate

C10H20N2O2

结构：CN(C(=O)OC(C)(C)C)[C@H]1CCNC1
HCID7171888

tert-Butyl methyl[(3S)-pyrrolidin-3-yl]carbamate

C10H20N2O2

结构：O=S(=O)(Cl)c1cccc2c(Cl)ncc(Br)c12
HCID76851490

未命名化合物

结构：O=S(=O)(Cl)c1cccc2c(Cl)ncc(F)c12
HCID86613861

1-Chloro-4-fluoro-5-isoquinolinesulfonyl chloride

C9H4Cl2FNO2S

结构：CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)c2cccc3c(Cl)ncc(F)c23)C1
HCID87322580

未命名化合物

2 次

PRODUCTS

生成物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CNC1CCN(S(=O)(=O)c2cccc3c(O)ncc(F)c23)C1
HCID178482265

未命名化合物

PROCEDURE

实验过程

3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 27) can be prepared by using 1-chloro-4-fluoro-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.