HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (S)-3-(tert-Butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67243408 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242685 | — |
Reaction Steps
Intermediate 28s (30 mg) obtained in Step A mentioned above was added with 10% hydrogen chloride/methanol (4 ml), and the mixture was stirred at room temperature for 20 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b78ec07fbe95403a9474765641a0ee3a |
| Source note | uspto-grants-2013_04 |