Hydrochloride methanol → Hydrochloric Acid

HRID 1962464Notes

Reaction equation

HRID 1962464 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:29].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:29]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67243408(S)-3-(tert-Butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 67242685(S)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

Procedure

Intermediate 28s (30 mg) obtained in Step A mentioned above was added with 10% hydrogen chloride/methanol (4 ml), and the mixture was stirred at room temperature for 20 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b78ec07fbe95403a9474765641a0ee3a
Source dataset
uspto-grants-2013_04
Patent number
US08415372B2

Reaction notes

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