反应详情

Methyl 2-chloro-4-fluoro-5-phenyl-1H-pyrrole-3-carboxylate (0.92 mg), 10% palladium carbon (50% containing water, 0.20 g) and triethylamine (0.56 mL) were suspended in methanol (30 mL), and the mixture was stirred under a hydrogen atmosphere at room temperature for 2 hr. The reaction mixture was filtered through celite, and the insoluble material was washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=19:1→1:1) to give the title compound as a colorless solid (yield 0.69 g, 87%).

1. filtrationThe reaction mixture was filtered through celite
2. washthe insoluble material was washed with ethyl acetate
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=19:1→1:1)