(1R,2R)-2-aminocyclopentan-1-ol hydrochloride → HCID 49803585, compound

HRID 1962969Notes

Reaction equation

HRID 1962969 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([OH:23])=O)=[N:19][CH:20]=1.Cl.[NH2:25][C@@H:26]1[CH2:30][CH2:29][CH2:28][C@H:27]1[OH:31]>>[OH:31][C@H:27]1[CH2:28][CH2:29][CH2:30][C@@H:26]1[NH:25][C:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][N:19]=1)=[O:23]

Participants

3

Reactant 2

HCID 12886906(1R,2R)-2-aminocyclopentan-1-ol hydrochlorideHCID 666446485-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 49803585HCID 49803585, compoundYield 78%

Procedure

As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using trans-2-aminocyclopentanol hydrochloride instead of isopropylamine, to the title compound (100 mg, 78%), which was obtained as a white solid. MS: m/e=395.1 [M+H]+.

Sources & evidence

ORD record
ord-a899b961adb4457fbe6bae2b806d6256
Source dataset
uspto-grants-2013_04
Patent number
US08415379B2

Reaction notes

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