Lithium Bromide → 1-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one

HRID 1963042Notes

Reaction equation

HRID 1963042 reaction equation
Cl[CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[Br-:14].[Li+]>CC(C)=O>[Br:14][CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12]

Participants

4

Reactant 2

HCID 82050Lithium BromideHCID 884144671-Chloro-3-(3-fluoro-2-methyl-phenyl)-propan-2-one

Product 1

HCID 866706671-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-oneYield 93.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The compound of step 1 (3.20 g, 15.95 mmol) was dissolved in acetone (70 ml), and lithium bromide (11.08 g, 127.59 mmol) was added. The mixture was stirred overnight. The solvent was evaporated, the resulting solid was dissolved in EA and the solution washed twice with water followed by a saturated solution of sodium chloride, dried over sodium sulfate, filtered and evaporated to dryness. 3.66 g of the title compound were obtained as a white powder.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe resulting solid was dissolved in EA
  3. washthe solution washed twice with water
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-0017813294b64f21afa9f508a322291c
Source dataset
uspto-grants-2013_04
Patent number
US08415336B2

Reaction notes

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