HRID1963059

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID31275

1,4-Dioxane

C4H8O2

反应SMILES：CNC(=O)c1ccn2c(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)c(Cc3cccc(F)c3C)c(-c3ccccc3)c2c1

HCID67772174

未命名化合物

PRODUCTS

产物

反应SMILES：CNC(=O)c1ccn2c(C(=O)N3CCNCC3)c(Cc3cccc(F)c3C)c(-c3ccccc3)c2c1

HCID50906579

未命名化合物

收率 99.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

The compound of step 7 (0.065 g, 0.11 mmol) was dissolved in 1.1 ml of DCM and cooled to 0° C. and a 4 N solution of hydrogen chloride in dioxane (0.54 ml, 2.20 mmol) was added. The mixture was stirred at room temperature overnight and then evaporated to dryness under reduced pressure. The obtained solid was triturated several times with diethyl ether and dried in vacuo at 40° C. 0.053 g of the title compound were obtained in the form of 2-(3-fluoro-2-methyl-benzyl)-1-phenyl-3-(piperazine-1-carbonyl)-indolizine-7-carboxylic acid methylamide hydrochloride as a light yellow solid with the following characteristics:

WORKUP

后处理

customevaporated to dryness under reduced pressure
customThe obtained solid was triturated several times with diethyl ether
customdried in vacuo at 40° C

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-0ff3118ba2c0402f8f345a3ecc0bcb20
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08415336B2
来源说明: uspto-grants-2013_04

反应SMILES

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[N:24]3[C:19]([CH:20]=[C:21]([C:25](=[O:28])[NH:26][CH3:27])[CH:22]=[CH:23]3)=[C:18]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17]=2[CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:37]=2[CH3:43])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[CH3:27][NH:26][C:25]([C:21]1[CH:22]=[CH:23][N:24]2[C:19]([CH:20]=1)=[C:18]([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:17]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:37]=1[CH3:43])=[C:16]2[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15])=[O:28]