Hydrochloric Acid → HCID 50906792, compound

HRID 1963084Notes

Reaction equation

HRID 1963084 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[N:20]3[N:21]=[CH:22][C:23]([C:25](=[O:28])[NH:26][CH3:27])=[CH:24][C:19]3=[C:18]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17]=2[CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:37]=2[CH3:43])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[CH3:27][NH:26][C:25]([C:23]1[CH:22]=[N:21][N:20]2[C:16]([C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:15])=[C:17]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:37]=3[CH3:43])[C:18]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[C:19]2[CH:24]=1)=[O:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67772986HCID 67772986, compound

Product 1

HCID 50906792HCID 50906792, compoundYield 93.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound of step 12 (0.150 g, 0.260 mmol) in 2.6 ml of DCM was added a 4 N solution of hydrogen chloride in dioxane (0.64 ml, 2.56 mmol). The mixture was stirred at room temperature for 5 h and then evaporated to dryness. The obtained solid was triturated several times with diethyl ether and dried in vacuo at 50° C. to give 0.118 g of the title compound in the form of 6-(3-fluoro-2-methyl-benzyl)-5-phenyl-7-(piperazine-1-carbonyl)-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methylamide hydrochloride as a pale orange solid with the following characteristics:

Workup

  1. customevaporated to dryness
  2. customThe obtained solid was triturated several times with diethyl ether
  3. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-b68fcccd9a4e4a90ad42e956a5abfddf
Source dataset
uspto-grants-2013_04
Patent number
US08415336B2

Reaction notes

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