HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-pyridylacetate → 2-(3-Fluoro-2-methyl-benzyl)indolizine-1-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-pyridylacetate | HCID 74264 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one | HCID 86670667 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(3-Fluoro-2-methyl-benzyl)indolizine-1-carboxylic acid methyl ester | HCID 67772559 | 61.3% |
Reaction Steps
The compound of step 1 (3.89 g, 15.88 mmol), pyridin-2-ylacetic acid methyl ester (1.65 g, 10.92 mmol) and sodium hydrogencarbonate (4.59 g, 54.60 mmol) in butan-2-one (43 ml) were heated under reflux for 24 h. The solid was removed by filtration and the filtrate was concentrated. The residue was purified by silica gel chromatography (HEP/EA) to give 1.99 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415336B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e3dcd27bd7a74630a1a0df74d7f12153 |
| Source note | uspto-grants-2013_04 |