反应详情

The compound of step 1 (3.89 g, 15.88 mmol), pyridin-2-ylacetic acid methyl ester (1.65 g, 10.92 mmol) and sodium hydrogencarbonate (4.59 g, 54.60 mmol) in butan-2-one (43 ml) were heated under reflux for 24 h. The solid was removed by filtration and the filtrate was concentrated. The residue was purified by silica gel chromatography (HEP/EA) to give 1.99 g of the title compound.

1. temperatureunder reflux for 24 h
2. customThe solid was removed by filtration
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by silica gel chromatography (HEP/EA)