反应详情

温度

90 °C

The compound of step 3 (250 mg, 0.67 mmol) was dissolved in dioxane (10 ml) and treated with 10 ml of an aqueous 10 N solution of sodium hydroxide. The mixture was heated to 90° C. for 12 h, cooled to room temperature and neutralized with dilute hydrochloric acid. The aqueous phase was extracted with DCM and the combined organic phases dried over sodium sulfate and filtered. The solution was evaporated to give 258 mg of the crude title compound which was used in the next step without purification.

1. extractionThe aqueous phase was extracted with DCM
2. dry with materialthe combined organic phases dried over sodium sulfate
3. filtrationfiltered
4. customThe solution was evaporated