HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 66731420, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 66732375 | HCID 66732375 | — |
| Product | HCID 66731420 | HCID 66731420 | — |
Reaction Steps
The compound was prepared as described in Reference Compound 1, Step 3 from crude 2-isobutyl-piperidine-4-carboxylic acid methyl ester (2.6 g, 13.0 mmol), DIPEA (4.55 mL, 26.1 mmol) and methyl chloroformate (1.31 mL, 17.0 mmol) and subsequently LiOH (1.3 equivalents) which yielded crude 2-isobutyl-1-(methoxycarbonyl)piperidine-4-carboxylic acid. MS m/z 242 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415378B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4ed59938df2e4bd2806413a01e420642 |
| Source note | uspto-grants-2013_04 |