Lithium Hydroxide → HCID 66731420, compound

HRID 1963112Notes

Reaction equation

C[O:2][C:3]([CH:5]1[CH2:10][CH2:9][NH:8][CH:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:6]1)=[O:4].CCN(C(C)C)C(C)C.Cl[C:25]([O:27][CH3:28])=[O:26].[Li+].[OH-]>>[CH2:11]([CH:7]1[CH2:6][CH:5]([C:3]([OH:2])=[O:4])[CH2:10][CH2:9][N:8]1[C:25]([O:27][CH3:28])=[O:26])[CH:12]([CH3:14])[CH3:13]

Participants

Reactant 4

HCID 3939Lithium Hydroxide

HCID 6586Methyl chloroformate

HCID 81531Diisopropylethylamine

HCID 66732375HCID 66732375, compound

Product 1

HCID 66731420HCID 66731420, compound

Procedure

The compound was prepared as described in Reference Compound 1, Step 3 from crude 2-isobutyl-piperidine-4-carboxylic acid methyl ester (2.6 g, 13.0 mmol), DIPEA (4.55 mL, 26.1 mmol) and methyl chloroformate (1.31 mL, 17.0 mmol) and subsequently LiOH (1.3 equivalents) which yielded crude 2-isobutyl-1-(methoxycarbonyl)piperidine-4-carboxylic acid. MS m/z 242 (M−H)−.

Workup

customThe compound was prepared

Sources & evidence

ORD record: ord-4ed59938df2e4bd2806413a01e420642
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415378B2

Reaction notes

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