Methyl chloroformate → HCID 66734916, compound

HRID 1963167Notes

Reaction equation

HRID 1963167 reaction equation
Cl.[C:2]([C:6]1[S:10][C:9]([CH:11]2[CH2:16][CH:15]([C:17]([O:19][CH3:20])=[O:18])[CH2:14][CH2:13][NH:12]2)=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].CCN(C(C)C)C(C)C.Cl[C:31]([O:33][CH3:34])=[O:32]>C(Cl)Cl>[C:2]([C:6]1[S:10][C:9]([CH:11]2[CH2:16][CH:15]([C:17]([O:19][CH3:20])=[O:18])[CH2:14][CH2:13][N:12]2[C:31]([O:33][CH3:34])=[O:32])=[CH:8][CH:7]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 81531DiisopropylethylamineHCID 66732297HCID 66732297, compound

Product 1

HCID 66734916HCID 66734916, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Methyl 2-(5-tert-butylthiophen-2-yl)piperidine-4-carboxylate hydrochloride (2.36 g, 7.42 mmol) and DIPEA (3.24 mL, 18.56 mmol) were dissolved in DCM (30 mL). Methyl chloroformate (0.690 mL, 8.91 mmol) was added and the reaction mixture stirred at room temperature for 1 h. DCM (170 mL) was added. The organic phase was washed with 0.1 M HCl (2×200 mL), satd NaHCO3 (200 mL), dried with a phase separator and evaporated in vacuo yielding dimethyl 2-(5-tert-butylthiophen-2-yl)piperidine-1,4-dicarboxylate (2.490 g, 99%) as a dark oil. MS m/z 340 (M+H)+

Workup

  1. washThe organic phase was washed with 0.1 M HCl (2×200 mL), satd NaHCO3 (200 mL)
  2. customdried with a phase separator
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-11cb337df2d948a8b6fa7b6827321a65
Source dataset
uspto-grants-2013_04
Patent number
US08415378B2

Reaction notes

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