Hydrogen Bromide → HCID 46937585, compound

HRID 1963491Notes

Reaction equation

[O:1]=[C:2]1[CH:6]=[C:5]([C@H:7]2[CH2:12][CH2:11][N:10](C(OC)=O)[C@H:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:8]2)[O:4][NH:3]1.Br>>[C:17]1([C@@H:9]2[CH2:8][C@@H:7]([C:5]3[O:4][NH:3][C:2](=[O:1])[CH:6]=3)[CH2:12][CH2:11][NH:10]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 66734876HCID 66734876, compound

Product 1

HCID 46937585HCID 46937585, compoundYield 127.3%

Procedure

(2S,4S)-Methyl 4-(3-oxo-2,3-dihydroisoxazol-5-yl)-2-phenylpiperidine-1-carboxylate (249 mg, 0.82 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 3 mL, 42.82 mmol) and the mixture was stirred at room temperature for 16 h. The solvent was evaporated and the residue was purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2S,4S)-2-phenylpiperidin-4-yl)isoxazol-3(2H)-one (255 mg, 127%) (the isolated sample contained DMSO). 1H NMR (400 MHz, cdcl3) δ 2.10-2.43 (m, 4H), 3.21 (dt, 1H), 3.26-3.35 (m, 1H), 3.35-3.43 (m, 1H), 4.17 (dd, 1H), 5.73 (s, 1H), 7.34-7.48 (m, 5H). HRMS Calculated for [C14H16N2O2+H]+: 245.1290. Found: 245.1271.

Workup

customThe solvent was evaporated
customthe residue was purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm)

Sources & evidence

ORD record: ord-32664080ca2147828ef33b7ac560d16d
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415378B2

Reaction notes

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