反应详情

温度

60 °C

A mixture of 6-benzyl-5,6,7,8-tetrahydro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrido[3,4-d]pyrimidin-4-amine (0.742 g, 1.98 mmol), ammonium formate (1.25 g, 19.83 mmol) and palladium, 10% wt. on activated carbon (75 mg) in methanol (10 mL) is heated to 60° C. for 2 h. The mixture is cooled to r.t. and filtered over celite. The filtrate is concentrated under reduced pressure to give a white solid which is dissolved in water. The mixture is extracted twice with a 3:1 mixture of chloroform: isoproanol. The combined organic extracts are dried over sodium sulfate and concentrated to dryness to give the title compound.

1. temperatureThe mixture is cooled to r.t.
2. filtrationfiltered over celite
3. concentrationThe filtrate is concentrated under reduced pressure
4. customto give a white solid which
5. extractionThe mixture is extracted twice with a 3:1 mixture of chloroform
6. dry with materialThe combined organic extracts are dried over sodium sulfate
7. concentrationconcentrated to dryness