Ethanol heptane → HCID 66739232, compound

Participants

Reaction Steps

Benzyl 2-(1-methyl-1H-tetrazol-5-yl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (488 mg, 1.27 mmol) was subjected to chiral preparative HPLC (Column: Chiralpak AS (250×20), 5 μm particle size, mobile phase: Heptane/EtOH/DEA 60/40/0.1, flow rate 18 mL/min) to yield (2R,4S)-benzyl 2-(1-methyl-1H-tetrazol-5-yl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (231 mg, 47%), chiral purity 98% ee, Optical rotation [α]D20=+14.5 (acetonitrile, c=1)

Provenance & Evidence