Hydrogen Bromide → HCID 66732368, compound

HRID 1963608Notes

Reaction equation

HRID 1963608 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[CH2:4][C@@H:5]1[CH2:10][C@H:9]([C:11]2[O:15][NH:14][C:13](=[O:16])[CH:12]=2)[CH2:8][CH2:7][N:6]1C(OC)=O.Br>>[F:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[CH2:4][C@@H:5]1[CH2:10][C@H:9]([C:11]2[O:15][NH:14][C:13](=[O:16])[CH:12]=2)[CH2:8][CH2:7][NH:6]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 66732607HCID 66732607, compound

Product 1

HCID 66732368HCID 66732368, compoundYield 70%

Procedure

(2S,4R)-Methyl 2-(2,5-difluorobenzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (499 mg, 1.42 mmol) (from example 124, step 3) was dissolved in hydrogen bromide (33% in acetic acid, 10 mL, 57.10 mmol) and the mixture stirred at room temperature for 22 h. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2S,4R)-2-(2,5-difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one (292 mg, 70%). 1H NMR (600 MHz, cd3od) δ 1.49 (q, 1H), 1.71 (dq, 1H), 2.00-2.08 (m, 2H), 2.83-2.91 (m, 2H), 2.93-3.00 (m, 2H), 3.25-3.31 (m, 1H), 3.33-3.37 (m, 1H), 5.50 (s, 1H), 6.99-7.12 (m, 3H). HRMS Calculated for [C15H16F2N2O2+H]+: 295.1258. Found: 295.1254

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm)

Sources & evidence

ORD record
ord-8e906c2485ba4ce591ffc86840b4b564
Source dataset
uspto-grants-2013_04
Patent number
US08415378B2

Reaction notes

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