Hydrogen Bromide → HCID 66732159, compound

HRID 1963620Notes

Reaction equation

HRID 1963620 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([F:25])[CH:24]=1)[CH2:5][C@@H:6]1[CH2:11][C@H:10]([C:12]2[O:16][NH:15][C:14](=[O:17])[CH:13]=2)[CH2:9][CH2:8][N:7]1C(OC)=O.Br>>[F:25][C:23]1[CH:22]=[C:4]([CH:3]=[C:2]([F:1])[CH:24]=1)[CH2:5][C@@H:6]1[CH2:11][C@H:10]([C:12]2[O:16][NH:15][C:14](=[O:17])[CH:13]=2)[CH2:9][CH2:8][NH:7]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 66732293HCID 66732293, compound

Product 1

HCID 66732159HCID 66732159, compoundYield 19%

Procedure

(2S,4R)-Methyl 2-(3,5-difluorobenzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.789 g, 2.24 mmol) (from example 130, step 3) was dissolved in hydrogen bromide (33% in acetic acid, 17.65 mL, 100.77 mmol) and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2S,4R)-2-(3,5-difluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one (123 mg, 19%). 1H NMR (600 MHz, dmso) δ 1.07 (q, 1H), 1.33 (dq, 1H), 1.71-1.78 (m, 2H), 2.49-2.56 (m, 1H), 2.57-2.71 (m, 3H), 2.72-2.78 (m, 1H), 2.94-2.99 (m, 1H), 5.67 (s, 1H), 6.89-6.94 (m, 2H), 7.00 (tt, 1H). HRMS Calculated for [C15H16F2N2O2+H]+: 295.1258. Found: 295.1248

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm)

Sources & evidence

ORD record
ord-b8aa40909ab94ba297db9bf0bc1ec59c
Source dataset
uspto-grants-2013_04
Patent number
US08415378B2

Reaction notes

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