HCID 86627028, compound → HCID 57572455, compound

HRID 1963662Notes

Reaction equation

HRID 1963662 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])=[CH:10][CH:9]=2)[CH:7]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH2:24][C:25]([OH:27])=[O:26])=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:15])=[O:16])=[CH:12][CH:13]=2)[CH:7]=1

Participants

3

Reactant 1

HCID 86627028HCID 86627028, compound

Product 1

HCID 57572455HCID 57572455, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

The title compound was prepared from the product of step (iii) (0.6 g) which was stirred in TFA/DCM (1:1, 10 ml) overnight. The mixture was concentrated under reduced pressure to give an oil. The residue was purified by reverse phase HPLC, yield 0.31 g.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customto give an oil
  3. customThe residue was purified by reverse phase HPLC, yield 0.31 g

Sources & evidence

ORD record
ord-c7661fd39e314245a982ed2ca6543da6
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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