反应详情

2-(2-fluoro-5-nitrophenyl)-2-methyloxirane (1 eq) was dissolved in ethyl ether (1 mL) under nitrogen. BF3-etherate (0.87 eq) was added dropwise at room temperature and after complete addition solution was allowed to stir for 1 h. Solution was then quenched with water, extracted with ethyl ether. Organics washed with brine, dried with sodium sulfate and concentrated. Crude product was purified using flash chromatography (85% Hex:15% EtOAc) on silica to afford 2-(2-fluoro-5-nitrophenyl) propanal.

1. customSolution was then quenched with water
2. extractionextracted with ethyl ether
3. washOrganics washed with brine
4. dry with materialdried with sodium sulfate
5. concentrationconcentrated
6. customCrude product was purified