Hydrochloric Acid → HCID 67020462, compound

HRID 1963803Notes

Reaction equation

HRID 1963803 reaction equation
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>[OH-].[Na+]>[ClH:20].[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18997131HCID 18997131, compound

Product 1

HCID 67020462HCID 67020462, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g),

Workup

  1. customobtained
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated by evaporation at reduced pressure
  4. customthe solid thus obtained
  5. filtrationwas filtered
  6. customdried in a stove under vacuum

Sources & evidence

ORD record
ord-d308e8a1450248f09072ba60de7b5939
Source dataset
uspto-grants-2013_04
Patent number
US08415476B2

Reaction notes

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