反应详情

A mixture of tert-butyl(trans-4-(5′-chloro-6-fluoro-2,4′-bipyridin-2′-yl-amino)cyclohexyl)methylcarbamate (390 mg, 0.897 mmol), 4M HCl in Dioxane (5604 μl, 22.42 mmol) reaction mixture was stirred at ambient temperature for 1 hr. The crude reaction mixture mixture was concentrated, and then dried under high vacuum to a constant mass giving 335 mg of the title compound as a HCL salt. LCMS (m/z): 335.1 (MH+), retention time=0.51 min.

1. customThe crude reaction mixture mixture
2. concentrationwas concentrated
3. customdried under high vacuum to a constant mass