Hydrochloric Acid → HCID 178511265, compound

HRID 1963857Notes

Reaction equation

HRID 1963857 reaction equation
C(OC(=O)[NH:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([NH:15][C:16]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[N:23]=3)[C:19]([Cl:29])=[CH:18][N:17]=2)[CH2:11][CH2:10]1)(C)(C)C.Cl.O1CCOCC1>>[NH2:7][CH2:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([NH:15][C:16]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[N:23]=3)[C:19]([Cl:29])=[CH:18][N:17]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178453634HCID 178453634, compound

Product 1

HCID 178511265HCID 178511265, compoundYield 111.5%

Procedure

A mixture of tert-butyl(trans-4-(5′-chloro-6-fluoro-2,4′-bipyridin-2′-yl-amino)cyclohexyl)methylcarbamate (390 mg, 0.897 mmol), 4M HCl in Dioxane (5604 μl, 22.42 mmol) reaction mixture was stirred at ambient temperature for 1 hr. The crude reaction mixture mixture was concentrated, and then dried under high vacuum to a constant mass giving 335 mg of the title compound as a HCL salt. LCMS (m/z): 335.1 (MH+), retention time=0.51 min.

Workup

  1. customThe crude reaction mixture mixture
  2. concentrationwas concentrated
  3. customdried under high vacuum to a constant mass

Sources & evidence

ORD record
ord-ef0c02f53246441391d1832092483683
Source dataset
uspto-grants-2013_04
Patent number
US08415381B2

Reaction notes

Loading…