(4-((5'-chloro-2'-fluoro-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-yl)methanol → HCID 178495712, compound

HRID 1963970Notes

Reaction equation

HRID 1963970 reaction equation
[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][CH2:16][C:17]3([CH2:23][OH:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[N:10]=2)=[CH:4][C:5](F)=[N:6][CH:7]=1.[CH3:25][O:26][CH2:27][C@H:28]([NH:30][C@H:31]1[CH2:36][CH2:35][C@H:34]([NH2:37])[CH2:33][CH2:32]1)[CH3:29]>>[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][CH2:16][C:17]3([CH2:23][OH:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[N:10]=2)=[CH:4][C:5]([NH:37][C@H:34]2[CH2:33][CH2:32][C@H:31]([NH:30][C@H:28]([CH3:29])[CH2:27][O:26][CH3:25])[CH2:36][CH2:35]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 66937045(4-((5'-chloro-2'-fluoro-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-yl)methanolHCID 178495714HCID 178495714, compound

Product 1

HCID 178495712HCID 178495712, compound

Procedure

Following the same procedure as in Example 1b using (4-((5′-chloro-2′-fluoro-2,4′-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-yl)methanol (from step 4) and trans-N1-((R)-1-methoxypropan-2-yl)cyclohexane-1,4-diamine, the desired product was obtained. LCMS (m/z): 518.2 (MH+), retention time=0.47 min.

Sources & evidence

ORD record
ord-78e5da9d2eda40d787af739ba711a733
Source dataset
uspto-grants-2013_04
Patent number
US08415381B2

Reaction notes

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