2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid → 5-Chloro-2-[((2-oxo-2-[(3',4,5'-trimethylbiphenyl-3-yl)amino]ethoxy)acetyl)amino]benzoic acid

HRID 1963989Notes

Reaction equation

HRID 1963989 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([NH2:16])[CH:10]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:32])[CH2:26][O:27][CH2:28][C:29](O)=[O:30])=[C:20]([C:33]([O:35]C)=[O:34])[CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:32])[CH2:26][O:27][CH2:28][C:29](=[O:30])[NH:16][C:11]2[CH:10]=[C:9]([C:4]3[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=3)[CH:14]=[CH:13][C:12]=2[CH3:15])=[C:20]([CH:19]=1)[C:33]([OH:35])=[O:34]

Participants

3

Reactant 2

HCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acidHCID 610252723',4,5'-Trimethylbiphenyl-3-amine

Product 1

HCID 442509435-Chloro-2-[((2-oxo-2-[(3',4,5'-trimethylbiphenyl-3-yl)amino]ethoxy)acetyl)amino]benzoic acid

Procedure

Using the same method as in Example 1-(ii), 3′,4,5′-trimethylbiphenyl-3-amine was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-[((2-oxo-2-[(3′,4,5′-trimethylbiphenyl-3-yl)amino]ethoxy)acetyl)amino]benzoic acid.methyl ester (yield: 91%).

Sources & evidence

ORD record
ord-0f08190518044f79ae0752fdaf2ed9a6
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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