3-Bromoaniline → 2-[((2-[(3-Bromophenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid

HRID 1963997Notes

Reaction equation

HRID 1963997 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:24])[CH2:18][O:19][CH2:20][C:21](O)=[O:22])=[C:12]([C:25]([O:27]C)=[O:26])[CH:11]=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:21](=[O:22])[CH2:20][O:19][CH2:18][C:17]([NH:16][C:13]2[CH:14]=[CH:15][C:10]([Cl:9])=[CH:11][C:12]=2[C:25]([OH:27])=[O:26])=[O:24])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 115623-BromoanilineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 866533492-[((2-[(3-Bromophenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid

Procedure

Using the same method as in Example 1-(ii), 3-bromoaniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 2-[((2-[(3-bromophenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid.methyl ester (yield: 81%)

Sources & evidence

ORD record
ord-d64b7a01ac364715a34485e636e1167f
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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